Lowering Plasma Cholesterol by Raising LDL Receptors — Revisited
نویسندگان
چکیده
منابع مشابه
ApoA-IV phenotype affects diet-induced plasma LDL cholesterol lowering.
The National Cholesterol Education Program (NCEP) recommends that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/d, respectively (step 1 diet), in the general population to reduce plasma low-density lipoprotein cholesterol (LDL-C) levels and heart disease risk. We examined the LDL-C-lowering response to such a diet ...
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We can look back at >100 years of cholesterol research that has brought medicine to a stage where people at risk of severe or fatal coronary heart disease have a much better prognosis than before. This progress has not come about without resistance. Perhaps one of the most debated topics in medicine, the cholesterol controversy, could only be brought to rest through the development of new clini...
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Cardiovascular disease is still the main cause of death in the US. High plasma cholesterol, 51.9% of Americans have cholesterol levels of 200 mg/dl or higher and especially low-density lipoprotein (LDL) cholesterol, and high ratios of LDL to high-density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Plant stanol esters have been shown to be effective in reducing pla...
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Lowering LDL cholesterol reduces the risk of developing atherosclerotic events in CKD, but the effects of such treatment on progression of kidney disease remain uncertain. Here, 6245 participants with CKD (not on dialysis) were randomly assigned to simvastatin (20 mg) plus ezetimibe (10 mg) daily or matching placebo. The main prespecified renal outcome was ESRD (defined as the initiation of mai...
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BACKGROUND The short-term cholesterol-lowering efficacy of plant stanol esters has been open to debate, and the data from different clinical studies with hypercholesterolemic subjects are variable, partly due to lack of systematic studies. Therefore, we investigated the time in days needed to obtain the full cholesterol-lowering effect of stanol esters in hypercholesterolemic subjects. METHOD...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2012
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejme1202168